Multi-isocentric volumetric arc-based total body irradiation: radiation dose impact on oncological outcomes in patients receiving allogeneic hematopoietic cell transplantation.

ABSTRACT:

Background and purpose

Total body irradiation (TBI) is an important component of conditioning schedules. Data comparing different radiotherapy (RT) regimens in allogeneic hematopoietic cell transplantation (allo-HCT) remain limited. We aimed to evaluate the oncological outcomes of patients receiving different RT doses.

Materials and methods

All patients treated with multi-isocentric volumetric arc-based total body irradiation (VMAT-TBI) at a dose of ≥8 Grays (Gy) between 2021 and 2023 were included in this retrospective analysis. The RT regimens were either 8 Gy delivered in 4 bi-daily fractions (fx) or 12 Gy in 6 bi-daily fx. We evaluated the overall survival (OS), relapse-free survival (RFS), engraftment, and toxicities in both groups.

Results

Forty-two patients met

SUBMITTER: Romanowska A 

PROVIDER: S-EPMC12827096 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature