Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice.

ABSTRACT:

Introduction

Energy metabolic remodeling represents a critical pathological mechanism in myocarditis progression. Levocarnitine (LC), an essential cofactor for fatty acid oxidation, demonstrates potential in modulating cardiac metabolism. This study investigated the therapeutic effects of LC on myocardial energy metabolic remodeling and explored the underlying molecular mechanisms.

Methods

The experimental autoimmune myocarditis (EAM) mouse model was constructed using α-myosin. Cardiac function, myocardial inflammatory infiltration, and mitochondrial structure were evaluated using echocardiography, HE staining, and transmission electron microscopy, respectively. Metabolic parameters including free fatty acid (FFA), lactic acid (LAC), mitochondrial complex IV (COX IV) activit

SUBMITTER: Yang S 

PROVIDER: S-EPMC12827101 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature