Molecular profiling of signaling pathways involved in chicken ovarian follicle development by transcriptome sequencing.

ABSTRACT: Ovarian follicle development in chickens is a dynamic and closely controlled biological process crucial to avian reproduction. Each stage of folliculogenesis is characterized by distinct morphological and molecular alterations, regulated by complex signaling pathways. This study employed transcriptome sequencing to investigate the molecular landscape that governs the transition from primordial (PR) to primary (PM), small white (SW), and small yellow (SY) follicles. We found stage-specific activation of critical signaling pathways involved in follicle growth and development using thorough differential gene expression and pathway enrichment analyses. Our findings showed that the PI3K/AKT/mTOR signaling pathway was highly elevated throughout the shift from PR to PM follicles, highlighting its

SUBMITTER: Wadood AA 

PROVIDER: S-EPMC12827103 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature