Risk factors for cancer and the importance of screening in adult recipients of living-donor kidney transplant.

ABSTRACT:

Introduction

The incidence of cancer after kidney transplantation (KT) increases owing to the use of immunosuppressive (IS) medications, which may lead to death with a functioning graft (DWFG) and reduced long-term graft survival. However, the effect of IS medications, including their blood levels, on cancer development before graft failure remains underexplored.

Methods

This single-center retrospective cohort study involved 1274 living-donor KTs performed between January 2008 and December 2021. Cancer was diagnosed in 141 recipients before graft failure. DWFG and mortality-free survival were compared between recipients with and those without cancer before graft failure. Multivariable Cox regression analysis was used to identify risk factors for cancer. Trough levels of IS m

SUBMITTER: Hiramitsu T 

PROVIDER: S-EPMC12827106 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature