Unveiling bioactive compounds in kola nut seeds: GC-MS identification and computational analysis for anticancer potential.

ABSTRACT:

Introduction

Cancer continues to pose a critical global health challenge, with conventional therapies often limited by efficacy and adverse side effects. In search of safer and more effective treatments, medicinal plants offer a treasure trove of bioactive compounds with therapeutic potential. Kola nut (Cola spp.), a tropical evergreen native to the African rainforests, has long been valued in traditional medicine and as a natural stimulant.

Methods

This study explores the anticancer potential of kola nut seeds extract by first identifying its chemical constituents through gas chromatography-mass spectrometry (GC-MS), followed by molecular docking of selected compounds against the cancer-associated target PI3Kα. A methanolic extract was fractionated using column chrom

SUBMITTER: Alshehri A 

PROVIDER: S-EPMC12827131 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature