Sequential salvage systemic therapy after immunotherapy in head and neck cancer: a real-world study.

ABSTRACT:

Background

In recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) there is no established standard therapy after progression to immune checkpoint inhibitors (ICI). Retrospective and limited prospective studies have suggested that salvage chemotherapy after ICI (SCAI) may outperform historical pre-ICI data. We evaluated cetuximab-based SCAI outcomes in a real-world setting.

Methods

Objective response rate (ORR), median duration of response (DoR), and median best percentage change in target lesions (PCTL) by Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST 1.1), and median progression-free survival (PFS) and overall survival (OS) with SCAI and with last chemotherapy before immunotherapy (LCBI) were assessed. Adverse events (AEs) by C

SUBMITTER: Cabezas-Camarero S 

PROVIDER: S-EPMC12827138 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature