Serum insulin-like growth factor-1 and epidemiological evidence of the risk of prostate cancer.

ABSTRACT:

Objective

To systematically evaluate the epidemiological association between serum insulin-like growth factor-1 (IGF-I) levels and the risk of prostate cancer, in order to provide evidence-based support for risk stratification and early prevention of prostate cancer.

Methods

In accordance with the PRISMA statement, major domestic and international databases were systematically searched. Cohort studies, case-control studies, and Mendelian randomization studies reporting the relationship between serum IGF-I and prostate cancer risk were included. A random-effects model was used to combine effect estimates, assess heterogeneity, and perform subgroup analysis and meta-regression. Sensitivity analysis and publication bias tests were used to evaluate the robustness of the results,

SUBMITTER: Fang B 

PROVIDER: S-EPMC12827141 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature