Liver fibrosis assessed via noninvasive liver fibrosis scores is associated with atherosclerotic cardiovascular disease in middle-aged and older patients with prediabetes.

ABSTRACT:

Background

Metabolic dysfunction-associated steatotic liver disease-related liver fibrosis is linked to an increased risk of atherosclerotic cardiovascular disease (ASCVD); however, its impact on patients with prediabetes remains unclear. The aim of our study was to investigate the associations between ASCVD and three noninvasive liver fibrosis scores, including the fibrosis-4 index (FIB-4), nonalcoholic fatty liver disease fibrosis score (NFS), and aspartate aminotransferase-to-platelet ratio index (APRI), in middle-aged and older patients with prediabetes.

Methods

In this cross-sectional study, a total of 7,409 patients with prediabetes aged 40 to 80 years were classified into two groups based on their ASCVD statuses. Logistic regression analysis was performed to explore t

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12827147 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature