Overweight worsens the metabolic presentation of type 1 diabetes mellitus in children.

ABSTRACT:

Introduction

The prevalence of both obesity and type 1 diabetes mellitus (T1DM) has increased globally over the last decades. Overweight and obesity affect individuals with T1DM and influence not only the autoimmune pathogenesis but also the long-term complications of T1DM. This study aimed to investigate the effect of excess body weight on the clinical presentation of T1DM.

Methods

We conducted a retrospective, single-center cohort study at the largest pediatric endocrinology center in Hungary. Data were collected from children diagnosed with T1DM between 2014 and 2023. A total of 994 patients' presentation parameters and anthropometric data were analyzed. Based on BMI Z-scores, patients were categorized into three groups (normal-weight, overweight, and obese). Metabolic pa

SUBMITTER: Muzslay E 

PROVIDER: S-EPMC12827166 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature