Mucosal DNA methylation reveals immune-related methylation profile and correlates with crohn's disease status.

ABSTRACT: Altered DNA methylation (DNAm) patterns have been proven to play a key role in Crohn's disease (CD) pathogenesis. However, DNAm and its association with disease status in Chinese CD remain unclear. This study systematically examines DNAm patterns in Chinese patients with CD and their association with disease status. By elucidating specific DNAm alterations involved in CD pathogenesis, it aims to provide a molecular foundation for early diagnosis, prognosis assessment, and personalized treatment strategies. In this study, 24 adult treatment-naïve patients with CD were enrolled between January 2022 and May 2023. We performed reduced representation bisulfite sequencing (RRBS) on paired inflamed and non-inflamed intestinal mucosa samples from these patients, and inflammation-specific and disea

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12827257 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature