Identifying gut microbiota composition disparities in autistic individuals and their unaffected siblings: correlations with clinical characteristics.

ABSTRACT: Recent research has begun to illuminate a potential link between autism spectrum disorder (ASD) and the microbial environment. The unaffected sibling design is a valuable approach to identifying markers and protective factors for the condition, particularly in Asian populations lacking specific data. We assessed 239 autistic individuals, 102 unaffected siblings (SIB), and 81 typically developing controls (TDC) aged 4 to 25 years. We analyzed fresh stool samples via 16S rRNA amplicon library preparation and Illumina V3V4 sequencing. We employed taxonomic diversity analysis and microbiota differential abundance analysis to discern variations in microbial composition. In addition, we analyzed the associations between microbiota profiles and autistic symptoms, emotional/behavioral problems, an

SUBMITTER: Chang JC 

PROVIDER: S-EPMC12827261 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature