Direct detection of SABRE-SHEATH hyperpolarization and spin-lattice relaxation of [1-¹³C]pyruvate.

ABSTRACT: Nuclear magnetism is typically investigated by perturbing the spin system with radio frequency pulses, but low polarization and detection using induction coils limit direct access to the longitudinal magnetization. The hyperpolarization technique SABRE-SHEATH requires ultra-low magnetic fields for spin order transfer; consequently, SQUID sensors with a frequency-independent sensitivity are well-suited for unperturbed detection in this regime. We demonstrate direct observation of hyperpolarization build up (T_B) and spin lattice relaxation (T₁) in [1-¹³C]pyruvate, hyperpolarized with SABRE-SHEATH at 150 nT and 500 nT. The values for T_B of 36 s and 26 s and T₁ of 40 s and 43 s, respectively, suggests a shift in dominant polarization trans

SUBMITTER: Myers JZ 

PROVIDER: S-EPMC12827285 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature