Comparative effects of intermittent fasting and calorie restriction on cardiovascular health in adults with overweight or obesity.

ABSTRACT: Cardiovascular disease (CVD) risk factors are a significant global health concern. Previous studies have demonstrated that lifestyle-based strategies such as 5:2 intermittent fasting (IF) and calorie restriction (CR) may improve blood pressure, lipid profiles, glycemic control, and cardiovascular risk scores. However, comparative evidence on their effects in real-world settings remains limited. This study aimed to compare the effects of 5:2 IF and CR on cardiovascular risk factors in overweight and obese adults. This longitudinal cohort study used data from the Iranian National Obesity Registry (IRNOR). A total of 82 participants were included (40 in the 5:2 IF group and 42 in the CR group). Participants followed either a 5:2 IF (500-600 kcal on fasting days, isocaloric on other days) or a

SUBMITTER: Abdollahpour N 

PROVIDER: S-EPMC12827324 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature