Exploring p53 isoforms: unraveling heterogeneous p53 tumor suppressor functionality in uveal melanoma.

ABSTRACT: Uveal melanoma (UM) is the most common intraocular tumor, and despite being rare, it accounts for nearly 13% of melanoma-related deaths. Indeed, patients with metastatic disease have typically survival rates of less than one year, with little improvement over the past few decades. Although TP53 mutations are uncommon in UM, recent findings highlight a dysfunctional p53 pathway in this cancer. Given its crucial role in mediating DNA damage responses, we analyzed the p53 protein functionality and downstream target activation in a panel of UM cell lines in response to standard-of-care treatments (i.e., cisplatin and proton-beam irradiation). Although most of the analyzed cells retained a wild-type p53, we observed a wide range of p53 protein stabilization and targets' activation. Recently, p5

SUBMITTER: Bartolomei L 

PROVIDER: S-EPMC12827457 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature