FAM3A drives uncoupling of muscle lipid accumulation and insulin resistance depending on insulin receptor.

ABSTRACT: Obesity-associated insulin resistance (IR) is closely related to intramyocellular lipid accumulation in skeletal muscle. FAM3 metabolism regulating signaling molecule A (FAM3A) is expressed and secreted in almost all tissues. However, its biological roles and underlying mechanisms remain largely unknown. Here, we reported that abnormal lipid metabolism decreased the FAM3A level. To investigate the function of FAM3A, a transgenic mouse strain was generated, in which FAM3A protein was overexpressed systemically. Proteomic analyses revealed that proteins related to lipid metabolic processes, specifically fatty acid (FA) synthesis complex enzymes and adiponectin were upregulated in the skeletal muscles of the FAM3A-transgenic mice compared with those in the skeletal muscles of the wild-type co

SUBMITTER: Yang D 

PROVIDER: S-EPMC12827484 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature