Osteosarcopenia: key molecular mechanisms and translational perspectives.

ABSTRACT: The coexistence of osteoporosis and sarcopenia is recognized as a syndrome known as osteosarcopenia. As an aging-related disease, research into the molecular mechanisms of osteosarcopenia has gradually shifted from the study of single-organ pathology to the elucidation of multidimensional interactions. This review aims to construct a hierarchical framework of "intracellular - intercellular - systemic" to systematically elaborate on the pathogenesis of osteosarcopenia. Based on this foundation, it explores frontier interventions and their prospects for clinical transformation, including bone-targeting F6-(DSS)6-exo nanoparticles, miR-495, natural active compounds (resveratrol, nuciferine), Clostridium butyricum, and bimagrumab. Future research should focus on analyzing the microenvir

SUBMITTER: Pu Y 

PROVIDER: S-EPMC12827509 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature