Drug repurposing of Nifuratel against methicillin-resistant <i>Staphylococcus aureus</i> through proton motive force disruption.

ABSTRACT:

Introduction

The diminishing efficacy of conventional antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) necessitates novel therapeutic strategies. Drug repurposing represents a promising approach. This study investigates the antibacterial potential of Nifuratel, a repurposed agent, against MRSA.

Methods

In vitro antibacterial activity was assessed against type strains and clinical isolates via minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) assays. The propensity for resistance development was evaluated. Sub-MIC effects on key virulence phenotypes-biofilm formation, hemolysis, auto-aggregation, and surface spreading-were examined. The mechanism of action was investigated using transmission electron micros

SUBMITTER: She P 

PROVIDER: S-EPMC12827513 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature