Integrative single-cell atlas unveils heterogeneity and prognostic value of cancer-associated fibroblasts in gastric cancer.

ABSTRACT: Gastric cancer (GC) exhibits molecular heterogeneity and diverse immune cell infiltration patterns closely associated with patient prognosis. However, a comprehensive understanding of the variations in immune cell phenotypes among different patient subgroups still needs to be improved. In this study, we performed a detailed analysis of the tumor microenvironment in GC by integrating 200,466 single cells from 72 patients across six datasets. We classified patients into immune-deserted, B, T, and myeloid cell subtypes. Using genomic and clinical data from TCGA samples, we identified cellular components associated with tumor histology and genotypes. GC patients were stratified into immune-deserted, B cell, T cell, and myeloid cell subtypes, and we described the pathway and transcription facto

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC12827549 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature