Investigation of exJSRV LTR promoter activity based on transcription factor regulatory networks.

ABSTRACT: Ovine pulmonary adenocarcinoma (OPA) is a contagious respiratory tumor affecting sheep and goats, caused by the Jaagsiekte sheep retrovirus (exJSRV). The transcriptional regulation of exJSRV is primarily governed by its long terminal repeat (LTR) region, which interacts with host transcription factors. However, the specific host factors and signaling pathways that modulate exJSRV LTR activity remain poorly understood. To address this knowledge gap, we combined bioinformatic prediction with in vivo and in vivo experiments to identify and validate host transcription factors involved in regulating exJSRV LTR activity. Analyses using the hTFtarget and AnimalTFDB databases identified 53 potential transcription factors interacting with the exJSRV LTR. KEGG enrichment analysis revea

SUBMITTER: Du X 

PROVIDER: S-EPMC12827560 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature