The association of eight-year trajectories in total, cognitive-affective, and somatic depressive symptoms with incident stroke: a 10-year follow-up study using HRS and ELSA cohorts.

ABSTRACT:

Background

Earlier research has documented an association between depressive symptomatology and heightened stroke risk. However, prior work largely assessed depressive manifestations at isolated time points and failed to differentiate symptom subtypes. This investigation seeks to characterize the longitudinal progression of depressive symptoms via repeated measurement and explore their link to stroke risk by considering total depressive symptoms alongside cognitive-affective and somatic dimensions.

Methods

This prospective cohort study included individuals aged ≥ 45 years from the Health and Retirement Study (HRS) in the United States and the English Longitudinal Study of Ageing (ELSA) in the United Kingdom, excluding those with a history of stroke during the exposure period

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12827575 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature