Efficacy of fibrin sealant for bedside pleurodesis in patients with prolonged air leak after lung cancer surgery: a comparative study.

ABSTRACT:

Background

Prolonged air leak (PAL) represents a significant clinical problem after lung resection surgery, frequently causing extended hospital stays. Although several treatments exist, their effectiveness often remains limited. Fibrin sealant has attracted attention as a potential alternative due to its biocompatible properties, but strong evidence from controlled studies supporting its use for bedside pleurodesis remains insufficient. This study was conducted to compare the effectiveness and safety of fibrin sealant vs. 50% glucose solution in managing PAL following pulmonary resection for non-small cell lung cancer (NSCLC).

Methods

We performed a retrospective analysis of NSCLC patients who developed PAL (lasting ≥5 days) after surgery between January 2021 and May 2025.

SUBMITTER: Pan K 

PROVIDER: S-EPMC12827594 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature