Molecular evolution of the Wood-Ljungdahl pathway and the reductive glycine pathway in <i>Desulfobacterota</i>.

ABSTRACT: Carbon fixation is a fundamental metabolic process that sustains ecosystems, yet its origins and evolutionary history remain largely unresolved. In this study, we focused on the Wood-Ljungdahl (WL) pathway, which is considered one of the most ancient carbon fixation pathways, and the reductive glycine (rGly) pathway, which shares several reactions with the WL pathway. The evolutionary scenario of the two carbon fixation pathways was inferred in the phylum Desulfobacterota, which includes microorganisms that operate either the WL pathway or the rGly pathway for autotrophic growth. The timing of gene gain and loss events was inferred by gene presence/absence analyses for both pathways, together with phylogenetic analyses of their key enzymes. Our results suggested that the common ance

SUBMITTER: Wakashima T 

PROVIDER: S-EPMC12827605 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature