Atherogenic lipid indices and diabetic retinopathy in type 2 diabetes: a systematic review and meta-analysis.

ABSTRACT:

Objective

This study conducts a quantitative synthesis of existing evidence to evaluate the association of two novel atherogenic lipid indices-the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) and the atherogenic index of plasma (AIP)-with the prevalence and severity of diabetic retinopathy (DR) in individuals with type 2 diabetes mellitus (T2DM).

Methods

We systematically searched Cochrane Library, PubMed, Web of Science, Embase, CBM, CNKI, Wanfang, and Weipu for observational studies published before July 30, 2025. Cross-sectional, cohort, and case-control studies reporting AIP or TG/HDL-C data in T2DM patients with or without DR were eligible. Given the anticipated clinical and methodological diversity across observational studies, we prespecified

SUBMITTER: Liang Y 

PROVIDER: S-EPMC12827623 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature