Gut microbiota dysbiosis aggravates sepsis-induced lung injury by promoting neutrophil extracellular traps and suppressing host integrin defense.

ABSTRACT:

Background

The gut-lung axis is central to systemic inflammatory regulation, but the mechanisms by which gut microbiota dysbiosis aggravates sepsis-induced acute lung injury (ALI), particularly through neutrophil extracellular traps (NETs) and integrin signaling, remain unclear. Given the critical need for microbiota-based therapeutic strategies, this study investigates the mechanistic link between gut microbiota, NET formation, and pulmonary endothelial barrier dysfunction.

Methods

Using a cecal ligation and puncture (CLP) sepsis model, control, sepsis, and fecal microbiota transplantation (FMT) groups were compared. Lung injury was assessed via histopathology, wet/dry weight ratios, and bronchoalveolar lavage fluid (BALF) analysis. High-throughput RNA sequencing (GO/KEGG/P

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12827662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature