X-ray contrast-adjustable 3D printing for multimodal fusion of microCT and histology.

ABSTRACT:

Introduction

Phantoms and reference structures are essential tools for calibration and correlative imaging in pre-clinical and research applications of X-ray-based imaging. They serve as reference standards, ensuring consistency and accuracy in imaging results. However, generating individual phantoms often involves a complex creation process, high production costs, and significant time investment.

Material and methods

Conic reference structures were 3D printed using a mixture of UV-curable resin and X-ray contrast agents. These structures were then embedded together with lung specimens of SARS-CoV-2-infected rhesus macaques in a methyl methacrylate-based solution. The polymerized blocks were scanned using propagation-based phase-contrast microCT, a method chosen for its supe

SUBMITTER: Nolte P 

PROVIDER: S-EPMC12827677 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature