Clonal replacement by a P1-1/ST3 lineage in pediatric <i>Mycoplasma pneumoniae</i>, Jinan, China, 2021-2024.

ABSTRACT:

Introduction

After a prolonged lull during COVID-19 non-pharmaceutical interventions, Mycoplasma pneumoniae activity re-emerged in 2023 in multiple regions; in China this occurred against a backdrop of very high macrolide resistance. We conducted a retrospective single-center study of pediatric M. pneumoniae pneumonia in Jinan, comparing a pre-resurgence period (2021) with 2023-2024.

Methods

Clinical data were linked to whole-genome sequencing of 227 cultured isolates. We assessed lineage composition and relatedness using core-genome phylogenetics and SNP-threshold networks, and compared diversity and pan-genome functional profiles across major clades. Phenotypic antimicrobial susceptibility testing was performed.

Results

The proportion of severe cases i

SUBMITTER: Fang M 

PROVIDER: S-EPMC12827683 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature