Altered brain network dynamics and functional connectivity in subjective cognitive decline: an edge-centric network study.

ABSTRACT:

Purpose

To explore neurodynamic bases underlying subjective cognitive decline (SCD) based on edge-centric functional network.

Methods

211 SCD patients and 210 healthy controls (HC) were recruited from the Alzheimer's Disease Neuroimaging Initiative. Edge time series (ETS) were obtained based on resting-state functional magnetic resonance data. The top 10% co-fluctuation signals of all time points in ETS were extracted to construct the high-amplitude frame networks, and the co-fluctuation signals from the remaining time points were used to construct the low-amplitude frame networks. In both network states, the graph theory and network-based statistics (NBS) analyses were used to compare SCD and HC. The correlation of the imaging indicators with cognitive scores and apolipopro

SUBMITTER: Wei X 

PROVIDER: S-EPMC12827695 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature