A novel non-invasive diagnostic approach based on urine and blood: a cross-sectional study combining lipoarabinomannan antigen and interferon-gamma release assay for active tuberculosis.

ABSTRACT:

Purpose

To evaluate the diagnostic value of a combined strategy using the urine lipoarabinomannan (LAM) antigen assay and interferon-gamma release assay (IGRA) for active tuberculosis (TB), and to explore its potential as a non-invasive, sputum-independent diagnostic method for clinical application.

Patients and methods

A cross-sectional study design was adopted. Initially, 313 valid cases were selected for LAM performance evaluation, subsequently, 142 cases with both valid LAM and IGRA results were further selected from this group for combined test performance analysis. Using comprehensive clinical diagnosis as the reference standard, the diagnostic performance of LAM, IGRA, and two combination strategies (parallel: positive if either LAM or IGRA is positive; serial: positi

SUBMITTER: Cai L 

PROVIDER: S-EPMC12827696 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature