Late-onset polyvinylpyrrolidone allergy in a long-term hemodialysis patient: a case report of dialysis hypotension and gastrointestinal symptoms.

ABSTRACT: Polysulfone membranes are widely used in hemodialysis due to their excellent biocompatibility, with polyvinylpyrrolidone (PVP) serving as a key hydrophilic component. While PVP-related allergic reactions typically occur during initial exposure, delayed reactions in long-term dialysis patients present a unique diagnostic challenge due to their unexpected nature and similarity to routine complications. We report a case of delayed PVP allergy in a 69-year-old male who developed severe intradialytic hypotension and gastrointestinal symptoms after 13 months of stable hemodialysis treatment. Blood volume monitoring revealed a rapid 15% decrease within 30 min of dialysis initiation despite the absence of ultrafiltration, accompanied by marked eosinophilia (absolute eosinophil count: 13,266/μL) an

SUBMITTER: Narita T 

PROVIDER: S-EPMC12827821 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature