Efficacy of neonatal mouse muscle extracellular vesicles in skeletal muscle repair and regeneration.

ABSTRACT: Currently, effective treatments for skeletal muscle injury remain limited. The self-repair of skeletal muscle relies on the activation and differentiation of satellite cells (SCs), which fuse with damaged myofibers to form new fibers and thereby support muscle regeneration. However, in cases of severe injury, it is difficult for muscle tissue to fully restore its original structure and function, and its regenerative capacity is often markedly reduced. Thus, there is an urgent need to develop therapies that enhance muscle repair and restore physiological function. In this study, we investigated extracellular vesicles derived from neonatal mouse skeletal muscle (NMM-EVs), which are enriched in cargo from Pax7⁺ myogenic progenitor cells. We hypothesized that NMM-EVs could enhance SC activatio

SUBMITTER: Liu C 

PROVIDER: S-EPMC12827838 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature