HDL function and composition in atherothrombotic cardiovascular disease with very high HDL-C.

ABSTRACT:

Background

Emerging evidence demonstrates a J-shaped relationship between HDL-C levels and atherosclerotic cardiovascular disease (ASCVD) with very high HDL-C concentrations paradoxically associated with increased ASCVD events. This study aims to determine whether individuals with very high HDL-C (>80 mg/dL) and ASCVD exhibit altered HDL composition and impaired HDL functionality.

Methods

We investigated the HDL profile and functionality in 49 subjects (mean age: 62 ± 2 years, 83% female) with very high HDL-C levels (>80 mg/dL), including 23 with ASCVD. All ASCVD patients and 46% of those without ASCVD (non-ASCVD) were on lipid-lowering treatment.

Results

Plasma atherogenic lipoprotein-cholesterol levels were significantly lower in ASCVD patients than in those without

SUBMITTER: Padro T 

PROVIDER: S-EPMC12827843 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature