Albumin, urea-to-albumin ratio, or the albumin-to-creatinine ratio to predict outcomes in heart failure with mildly reduced ejection fraction.

ABSTRACT:

Background

This study investigates the prognostic impact of albumin, the urea-to-albumin ratio (UAR), and albumin-to-creatinine ratio (ACR) in patients with heart failure with mildly reduced ejection fraction (HFmrEF), since hypoalbuminemia, renal disease and malnutrition often coincide with heart failure (HF).

Methods

Consecutive patients hospitalized with HFmrEF at one university medical centre were retrospectively included from 2016 to 2022. Patients were stratified into quartiles based on albumin, the UAR, and ACR. The primary endpoint was all-cause mortality at 30 months (median follow-up), key secondary endpoint was long-term HF-related rehospitalization.

Results

The study cohort comprised 2,061 patients with HFmrEF with a median albumin level of 32.4 g/L. Album

SUBMITTER: Schmitt A 

PROVIDER: S-EPMC12827846 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature