Hypochlorous Acid-Responsive Prodrug Nanoplatform for Synergistic Cancer Immunotherapy.

ABSTRACT: Immunotherapy offers a promising paradigm for cancer treatment, but its efficacy is often constrained by tumor heterogeneity and the immunosuppressive tumor microenvironment. Herein, we constructed a multifunctional nanoplatform (termed MD1a NP) designed to elicit personalized antitumor immunity and overcome tumor immunosuppression by co-assembling a hypochlorous acid (HOCl)-responsive methylene blue (MB)-doxorubicin (DOX) dimer prodrug with a stimulator of interferon genes (STING) agonist (1a). Following intravenous administration, elevated intratumoral HOCl triggers the activation and release of MB and DOX, inducing nanoparticle disassembly and facilitating the liberation of 1a. Upon near-infrared laser irradiation, MB-mediated photodynamic therapy synergizes with DOX-induced chemotherap

SUBMITTER: Xia S 

PROVIDER: S-EPMC12827883 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature