Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m⁶A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma.

ABSTRACT: Insufficient radiofrequency ablation (IRFA) of hepatocellular carcinoma (HCC) leads to alterations in epigenetic properties such as N ⁶-methyladenosine (m⁶A) RNA methylation in tumor cells, which creates an immune-suppressive tumor microenvironment capable of promoting residual tumor growth and recurrence and affecting the efficacy of RFA. In this study, the constructed STM-Mn@OMVs, which were produced through the rational functionalisation of bacterial-derived OMVs with Mn²⁺ ions and the methylation inhibitor STM2457, were found to effectively activate antitumor immunity. Our study shows that STM-Mn@OMVs can effectively promote dendritic cells (DCs) maturation, T cell activation, and STING pathway activation after endocytosis by cells, thus promotin

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC12827888 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature