Comparing three induction regimens for nasopharyngeal carcinoma: a propensity score-matched analysis.

ABSTRACT:

Background

Induction chemotherapy (IC) regimens such as gemcitabine plus cisplatin (GP), docetaxel plus cisplatin plus fluorouracil (TPF), and paclitaxel plus cisplatin (TP) are optional clinical options for locoregionally advanced nasopharyngeal carcinoma (LA-NPC).

Objectives

This study aims to evaluate the efficacy and toxicity profiles of the GP, TPF, and TP induction regimens in LA-NPC.

Design

This was a retrospective study.

Methods

This multicenter retrospective study enrolled 722 patients with stage III-IVA LA-NPC who received GP, TPF, or TP IC. Propensity score matching (PSM) was performed before comparing survival outcomes and acute grades 3-4 toxicities among the three groups. Survival outcomes included the overall survival (OS), failure-free survival

SUBMITTER: Dai J 

PROVIDER: S-EPMC12827918 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature