A general strategy for generating expert-guided, simplified views of ontologies.

ABSTRACT: Annotation of biomedical entities with widely used, well-structured ontologies and ontology-aware tools ensures data and analyses are Findable, Accessible, Interoperable, and Reusable (FAIR). Standardized terms with synonyms support lexical search, while ontology structure enables biologically meaningful grouping of annotations, such as by location and type. However, ontologies serving diverse communities are often more complex than needed for specific applications, creating barriers to adoption by researchers and resource developers. For example, cell atlases often attempt simplifications by manually building term hierarchies linking to cell type and anatomy ontologies, but these may include relationship types unsuitable for grouping annotations. We present tools for validating human expe

SUBMITTER: Caron AR 

PROVIDER: S-EPMC12827952 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature