Aiolos restricts the generation of antigen-inexperienced, virtual memory CD8⁺ T cells in mice.

ABSTRACT: CD8⁺ virtual memory T (T_VM) cells rapidly respond to infection via antigen-independent bystander effector functions. While it is recognized that T_VM cells arise independently of foreign antigen encounter, the mechanisms governing their development are not fully understood. Here, we identify the Ikaros transcription factor Aiolos as a negative regulator of T_VM cell programming. We observe enhanced frequencies and numbers of T_VM in the spleen, liver, and blood of unchallenged Aiolos-deficient (Ikzf3^-/-) mice and in the lungs 1-day post-infection with influenza A virus (IAV). Furthermore, Ikzf3^-/- T_VM cells produce elevated IFN-γ and granzyme B in response to cytokine stimulation. Importantly, Aiolos-defic

SUBMITTER: Pokhrel S 

PROVIDER: S-EPMC12827986 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature