Gender differences in gray matter volume of the anterior cingulate cortex and suicidal ideation in patients with major depressive disorder: evidence from the REST-meta-MDD project.

ABSTRACT: Patients with major depressive disorder (MDD) have gender differences in many aspects, including suicidal ideation (SI) and grey matter volume (GMV). The relationship between GMV of the anterior cingulate cortex (ACC) and SI in patients with MDD is unknown, especially whether there is gender difference in this relationship. The purpose of this study was to explore gender differences in SI, GMV of the ACC and their relationship in patients with MDD in China, which has not been reported yet. As part of the REST-meta-MDD consortium, 246 patients with MDD and 235 healthy controls were recruited, including 123 MDD patients with SI and 123 MDD patients without SI. All participants underwent magnetic resonance imaging (MRI) brain scans. The 17-item Hamilton Depression Rating Scale (HAMD) was used

SUBMITTER: Xia L 

PROVIDER: S-EPMC12828052 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature