How Pragmatic Are Sarcopenia Intervention Studies? A Systematic Review.

ABSTRACT:

Background

Sarcopenia is an age-related muscle disease often accompanied by comorbidities, mobility issues and cognitive decline, which can limit treatment adherence in older adults. Owing to the reversible nature of sarcopenia, there has been a growing number of randomized controlled trials conducted in recent years. Yet, many randomized controlled trials (RCTs) are conducted under ideal conditions (explanatory trials), limiting their real-world applicability. In contrast, pragmatic trials aim to better reflect the complexities of clinical practice.

Objective

This study is aimed at assessing the level of pragmatism in current sarcopenia RCTs and identifying design gaps to further improve the clinical relevance and feasibility of future trials in the real world.

Methods</

SUBMITTER: Van Heden S 

PROVIDER: S-EPMC12828071 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature