Association Between the Triglycerides-to-High-Density Lipoprotein-Cholesterol (TG/HDL-C) Ratio and Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies.

ABSTRACT:

Background

The relationship between the triglycerides-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the risk of developing chronic kidney disease (CKD) remains unclear, as CKD is a major health challenge worldwide. This study aimed to investigate the association between the TG/HDL-C ratio and the risk of developing CKD.

Methods

To find studies that examined the association of TG/HDL-C ratio (without stratification restrictions for TG/HDL-C) with CKD or renal disorders, PubMed, Embase, Scopus, Google Scholar, and Web of Science databases, as well as study references, were searched by two independent investigators with no time limit until July 31, 2025 by related MeSH Terms. Heterogeneity among studies was assessed using the Cochran's Q and I² tests.

SUBMITTER: Bahardoust M 

PROVIDER: S-EPMC12828072 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature