Attenuation of <i>Clostridioides difficile</i> Infection by <i>Clostridium hylemonae</i>.

ABSTRACT: Clostridioides difficile infection (CDI) is a bacterial infection of the colon that can cause diarrhea and colitis. The use of antimicrobials disrupts the intestinal microbiota, weakening colonization resistance and creating an environment in which C. difficile can establish infection. It is, therefore, necessary to identify specific bacteria that are helpful for the recovery of the intestinal microbiota in individuals with CDI. Previous studies have identified several strains that showed a negative correlation with C. difficile. Among these strains, C. hylemonae DSM 15053, which possesses the bai operon similar to Clostridium scindens, was selected. To test this hypothesis, we utilized a CDI mouse model and evaluated the inhibitory effect of C.

SUBMITTER: Choi S 

PROVIDER: S-EPMC12828130 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature