Skeletal muscle-specific PGC-1α-b overexpression prevents eccentric contraction-induced muscle injury through an utrophin-independent pathway in mice.

ABSTRACT: Slower oxidative fibers are more resistant to eccentric contraction (ECC)-induced muscle damage than fast-twitch glycolytic fibers, but the mechanisms remain unclear. This study investigated the roles of the exercise-inducible PGC-1α isoform PGC-1α-b and utrophin in protecting against ECC-induced damage. ECCs were induced by supramaximal electrical stimulation of the left triceps surae in C57BL/6N wild-type (WT), PGC-1α-b transgenic (Tg), utrophin knockout (Utrn KO), and PGC-1α-b Tg/Utrn KO mice. Although the proportion of fast-type myosin heavy chain (MyHC) IIb in the gastrocnemius muscle was modestly lower in PGC-1α-b Tg and PGC-1α-b Tg/Utrn KO mice than in WT and Utrn KO mice, MyHC IIb remained the predominant isoform. At 3 days post injury (dpi), WT and Utrn KO mice exhibited reduced m

SUBMITTER: Naito A 

PROVIDER: S-EPMC12828171 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature