Genomic-Based Epidemiological Analysis of the Post-Pandemic <i>Mycoplasma pneumoniae</i> Resurgence.

ABSTRACT: Mycoplasma pneumoniae infections resurged globally in 2023-2024 following a significant decline during the coronavirus disease 2019 (COVID-19) pandemic. To understand the genomic epidemiology of this resurgence in China, a nationwide 1-year genomic surveillance identified 9907 patients infected with M. pneumoniae, resulting in an overall positive rate of 10.05%. We developed a hybrid capture-based targeted next-generation sequencing (hc-tNGS) assay, obtaining 271 high-quality genomes directly from clinical samples. Phylogenetic analysis of a global collection of 562 M. pneumoniae genomes identified six distinct lineages, including three newly emerged main Chinese clades (MCCs) that co-circulated across various regions of China. Among these MCCs, one clade, comprising P

SUBMITTER: Liu H 

PROVIDER: S-EPMC12828172 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature