Particle size distribution and concentration of Intralipid^® 20.

ABSTRACT:

Significance

Intralipid^® is widely used as a tissue-mimicking phantom due to its optical similarity to biological tissues, i.e., high scattering and low absorption of light. Accurate modeling of the optical behavior of phantoms requires detailed knowledge of the properties of its scatterers.

Aim

We aim to determine the particle size distribution (PSD), concentration, and refractive index (RI) of particles in Intralipid^® 20%.

Approach

Cryo-electron microscopy, three different flow cytometers, and microfluidic resistive pulse sensing were used to measure the size distribution and concentration of particles in Intralipid^® 20%. To select the most accurate technique, the measured volume fraction of lipid particles was calculated and compare

SUBMITTER: Shahsavari M 

PROVIDER: S-EPMC12828180 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature