CysDuF database: annotation and characterization of cysteine residues in domain of unknown function proteins based on cysteine post-translational modifications, their protein microenvironments, biochemical pathways, taxonomy, and diseases.

ABSTRACT: Experimental characterization and annotation of amino acids belonging to domains of unknown function (DUF) proteins are expensive and time-consuming, which could be complemented by computational methods. Cysteine, being the second most reactive amino acid at the catalytic sites of enzymes, was selected for functional annotation and characterization on DUF proteins. Earlier, we reported functional annotation of cysteine on DUF proteins belonging to the COX-II family. However, holistic characterization of cysteine functions on DUF proteins was not known, to the best of our knowledge. Here, we annotated and characterized cysteine residues based on post-translational modifications (PTMs), biochemical pathways, diseases, taxonomy, and protein microenvironment. The information on uncharacterized

SUBMITTER: Himaja D 

PROVIDER: S-EPMC12828279 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature