<i>Helicobacter pylori</i> Exploit Short-Chain Fatty Acids-Induced CAPZA1 Overexpression to Emerge CD44v9-Positive Stemness.

ABSTRACT:

Background and aims

Although Helicobacter pylori infects a large proportion of the global population, only a small subset of the infected individuals develop gastric cancer. The molecular mechanisms underlying the selective progression of gastric carcinogenesis are not fully understood. This study aimed to elucidate these mechanisms by focusing on CD44v9-positive cell generation in H pylori-infected gastric mucosa.

Methods

Using H pylori infection models in human gastric adenocarcinoma cells, mice, and mouse-derived gastric organoids, we examined the effects of short-chain fatty acids (SCFAs) on the induction of CD44v9-positive cells using western blotting and immunofluorescence. SCFA concentrations and microbiota compositions were analyzed in gastric ju

SUBMITTER: Tsugawa H 

PROVIDER: S-EPMC12828395 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature