Protective role of Zinc glycine in LPS-induced acute kidney injury in geese: Inhibition of oxidative stress and ferroptosis through Nrf2/GPX4 signaling.

ABSTRACT: Acute kidney injury (AKI) induced by lipopolysaccharide (LPS) is a critical pathological condition associated with inflammation, oxidative stress, and ferroptosis. Zinc glycine (Zn_Gly), a novel organic zinc complex, has demonstrated anti-inflammatory, antioxidant, and anticancer properties. To investigate the protective effects of Zn_Gly on LPS-induced AKI in geese, 180 one-day-old geese were randomly divided into three groups: control, LPS, and LPS+Zn_Gly (80 mg/kg). Dietary supplementation with Zn_Gly significantly reduced LPS and ROS production in geese. Moreover, serum creatinine, urea, uric acid, and LDH activity were markedly decreased following Zn_Gly supplementation in AKI-affected geese. Histopathological analysis showed that Zn_Gly markedly attenuated glomerular fragmentation, B

SUBMITTER: Zulfiqar Z 

PROVIDER: S-EPMC12828399 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature