AGEs promote the metastasis of colorectal cancer cells via centrosome amplification by KLF5-CEP57L1 axis.

ABSTRACT: Despite the accumulating evidence that diabetes and centrosome amplification (CA) are both associated with cancer cell metastasis, in particular the observations in gene-edited animal models, their relationships and the underlying molecular mechanisms remain unknown under pathophysiological conditions. In the present study, we examined if CA could serve as a biological link between diabetes and metastasis. Our results showed that, in vitro, advanced glycation end products (AGEs) promoted CA, migration, and invasion of HCT116 colorectal cancer cells, with the highest CA level in the migrated cell fraction, and upregulated FAM111B, which promoted epithelial-mesenchymal transition. Upon AGE treatment, Krüppel-like factor 5 (KLF5), Kelch-like (KLHL)13, and Cullin3 (CUL3) were downregulated and

SUBMITTER: Zhao JZ 

PROVIDER: S-EPMC12828400 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature