Striatal dopamine synthesis capacity in Parkinson's disease: Effects of age, sex, and body mass index in a large [¹⁸F]fluorodopa PET cohort.

ABSTRACT:

Background

Positron emission tomography (PET) using radioligand [¹⁸F]fluorodopa detects reduced striatal dopamine synthesis capacity in Parkinson's disease (PD) patients. Demographic factors such as sex and BMI are also associated with dopamine synthesis capacity. The combined contribution of demographic and clinical effects however remains elusive.

Material, aims, and methods

For this retrospective register-based study, we used baseline [¹⁸F]fluorodopa PET data acquired at the Turku PET Centre between the years 1988-2016 with three scanners (Ecat 931, GE Advance, HRRT). The data involved 350 adult human subjects, including 132 healthy controls, and 218 PD patients. The primary aim was to simultaneously investigate the effects of PD, age, sex and BMI on

SUBMITTER: Malen T 

PROVIDER: S-EPMC12828425 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature