Weight-band-based simplification of oral allometric miltefosine dosing in paediatric patients with visceral leishmaniasis.

ABSTRACT:

Background and objectives

An allometric miltefosine regimen dosed based on fat-free mass (FFM) is effective and safe in treating children with visceral leishmaniasis (VL). However, its complexity hinders successful implementation in endemic areas. We aimed to develop a simplified dosing based on weight bands (WBs) that achieves equivalent miltefosine exposure in a paediatric VL population using a simulation-based approach.

Methods

Utilizing demographic data from 9379 Eastern African paediatric VL patients, WHO-CDC growth curves were adjusted to create a realistic virtual paediatric VL population. The virtual children were given either an allometric FFM-based, a WB-based or a 2.5 mg/kg dosing of miltefosine per day. To compare the regimens, two pharmacokinetic metrics were de

SUBMITTER: Mazariegos Herrera A 

PROVIDER: S-EPMC12828427 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature